Resume, Benjamin Shapiro, University of Maryland

Benjamin Shapiro
Associate Professor
Department of Aerospace Engineering
University of Maryland at College Park
Joint appointment with Institute for Systems Research (ISR)
Affiliated with Fischell Department of Bioengineering and
Applied Math and Scientific Computation (AMSC) program

Address:	3178 Glenn L. Martin Hall, College Park, Maryland 20742
Phone:	(301) 405-4191
Email:	benshap@umd.edu

1. Personal Information

Research Interests

Modeling and control of micro and nano-scale systems for chemical, biological, and clinical applications.

My lab focuses on applications where control can dramatically improve or enable new system capabilities. For example, current applications include precision control of magnetic nano-particles to deep tissue targets, to tumors and inner ear infections, and control of single particles on chip for quantum dot placement, cell analysis, and biological sample preparation.
We work on all aspects of the path from initial concept to final use: from initial choice of novel and high-impact applications (drug delivery and QD control); to the basic science of system modeling, control theory and algorithm development; to optimization; experimental validation; and demonstration of utility (2 of my patents have already been licensed, 4 more are currently being considered for licensing).
My group is unique in combining advanced control with micro- and nano-scale bio-medical research, a combination that is meeting a strong unmet need both basic science research and clinical practice.

Professional Preparation

Fulbright Scholar (to Germany)
For precision control of magnetic drug delivery to focus chemotherapy to deep tissue tumors.
Host: Andreas Lubbe, Director Cecilienklinik (a 750 bed hospital), Bad Lippspringe, Germany, September-October 2009 and Summer 2010.
California Institute of Technology,
Biology Boot Camp, directed by Robert Phillips, Summer 2007.
California Institute of Technology,
Post-doctorate, Control and Dynamical Systems, August 1999 to April 2000.
California Institute of Technology,
Doctor of Philosophy in Control and Dynamical Systems, June 1999.
Thesis Title: “Passive Control of Flutter and Forced Response in Bladed Disks via Mistuning”.
Thesis Advisor Dr. Richard Murray.
Mistuning refers to unavoidable blade-to-blade variations in fans, turbines, and compressors of jet engines. A small amount of mistuning can dramatically change flutter boundaries and forced response of the jet engine. My thesis analyzed the effects of mistuning and found intentional mistuning patterns that robustly improved both stability and forced response.
Georgia Institute of Technology,
Bachelor of Science in Aerospace Engineering with Highest Honors, September 1995

Appointments

Jan 2009 – Jan 2010: Sabbatical at NIST (50%) and NIH (50%)
At NIST, project leader for on-chip control of particles and objects to nano-scale precision. Working with Dr. J. Alex Liddle at the Center for Nanoscale Science and Technology (CNST).
At NIH, research on magnetic drug delivery and mapping of genes and gene expression in human tissue samples. Working with Dr. Michael Emmert-Buck at Advanced Technology Center, NCI.
April 2006 – Present: Aerospace, University of Maryland, Associate Professor.
Joint appointment with Institute for Systems Research (ISR). Affiliated with Bioengineering graduate program and Applied Math and Scientific Computation (AMSC) program.
June 2000 – April 2006: Aerospace, University of Maryland, Assistant Professor.
Joint appointment with Institute for Systems Research (ISR). Affiliated with Bioengineering graduate program and Applied Math and Scientific Computation (AMSC) program.
Carried out research in modeling, design, and control of micro-scale systems, with a focus on micro-fluidic systems for aerospace and bio-chemical applications. Focused on demonstrating control of micro-scale systems from initial choice of novel applications, to modeling and control design, to final experimental verification of new micro-scale capabilities. Application themes include micro-fluidic devices for steering of cells, for lab-on-a-chip applications, for medical diagnostics (cancer screening, pathogen detection), and for quantum information devices; modeling and control of conducting plastic micro-actuators; micro-airfoil shape control; and control of chemotherapy-coated nano-particles in patients for targeted drug delivery. Teaching graduate courses in control theory (optimal and multi-variable control) and undergraduate courses in rigid body dynamics.
Aug 1999 - Dec 1999: Control and Dynamical Systems, Caltech, Instructor.
Taught CDS 110, an introductory controls course for undergraduates and starting graduates students at Caltech. (This was immediately after I completed my PhD at Caltech.)
Aug 1997 - Dec 1997: Aerospace/Mechanical, Cornell University, Visiting Instructor.
Taught the introduction to controls course for juniors, seniors, and beginning masters students. (Taught this course at Cornell for one semester while still a PhD student at Caltech.)
Summer 1996 - 1997: United Technologies Research Center, Visiting Researcher
Researched how mistuning (symmetry breaking) in the fans, compressors, and turbines of jet engines effected stability and forced response. A small amount of mistuning is unavoidable in engines due to variations from blade to blade. Studied mistuning effects on stability (1996) and forced response (1997), found robust optimal intentional mistuning patterns, collaborated with researchers at UTRC and Pratt & Whitney to experimentally verify PhD thesis predictions.

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2. Research, Scholarly, and Creative Activities
My students are marked by an asterix (*)

Books edited

J. Gorman, B.Shapiro, co-editors of “Feedback Control of Systems on the Micro- and Nano-Scales: from MEMS to Atoms”. To be published by Springer Verlag in 2010. The book is under preparation.

Chapters in books

M.Armani*,R.Probst*,B.Shapiro, “Fabricating Micro-Fluidic Channels Using a Vinyl Sign Plotter”, editors K.E.Herold, A.Rasooly chapter for “Lab on a Chip Technology: Fabrication and Microfluidics”. Caister Academic Press, August 2009.
B.Shapiro, “Control of Microfluidics” chapter entry for “Encyclopedia of Microfluidics and Nanofluidics”, editor D. Li. Springer Verlag, 2008.

Articles in Refereed Journals

Published and Accepted

M.Armani*, J.Rodriguez-Canales, J.Gillespie, M.Tangrea, H.Erickson, M.R.Emmert-Buck, B.Shapiro, E.Smela, “2D-PCR: A Method of Mapping DNA in Tissue Sections”, Laboratory on a Chip (LOC) journal (In press August 2009.)
S.Walker*, R.H.Nochetto, B.Shapiro, “Electrowetting with Contact Line Pinning: Computational Modeling and Comparisons with Experiments”, Physics of Fluids. (Accepted in final form August 2009). [On the dynamics of micro-flows actuated by electrically modified surface tension.]
M.E.Piyasena, R.Newby, B.Shapiro, E.Smela, “Electroosmotically Driven Microfluidic Actuators”. Sensors and Actuators B (published online July 2009).
J.West*, T.Otero, B.Shapiro, E.Smela, “Chronoamperometric Study of Conformational Relaxation in PPy(DBS)”, Journal of Physical Chemistry, vol 113, no 5, pg 1277-1293, 14 Jan 2009.
B.Shapiro, “Towards Dynamic Control of Magnetic Fields to Focus Magnetic Carriers to Targets Deep Inside the Body” (invited to submit from the 7th International Conference on the Scientific and Clinical Applications of Magnetic Carriers), Journal of Magnetism and Magnetic Materials, vol 321, no 10, pg 1594-1599 , 11 May 2009.
X.Wang, B.Shapiro, E.Smela, “Development of a Model for Charge Transport in Conjugated Polymers”, J. Phys. Chem. C, vol 113, no 1, pg 382-401, Jan 2009.
M. Tomizuka, L.A. Bergman, B. Shapiro, R.Shoureshi, B.F. Spencer, Jr., “Bio-inspired autonomous engineered systems”, Smart Structures and Systems, vol 3, no 4, Oct 2007.
M.Christophersen, B.Shapiro, E.Smela, “Characterization and Modeling of PPy Bilayer Microactuators. Part 1: Curvature”, Sensors and Actuators B: Chemical, vol 115, pg 596-609, 26 June 2006.
S.Walker*, B.Shapiro, “A Control Method for Steering Individual Particles Inside Liquid Droplets Actuated by Electrowetting”, Lab on a Chip Journal, vol 12, no 1, pg 1404 – 1407, 2005.
S.Walker*, B.Shapiro, “Modeling the Fluid Dynamics of Electro-Wetting On Dielectric (EWOD)”, Journal of Microelectromechanical Systems (JMEMS), vol 15, no 4, pg 986-1000, Aug 2006.
P.Mathai*, B.Shapiro, “Interconnection of Subsystem Reduced Order Models in the Electro-thermal Analysis of a Large System”, IEEE Transactions on Components and Packaging Technologies, vol 30, issue 2, pg 317 – 329, June 2007.
M.Armani*, S.Chaudhary*, R.Probst*, B.Shapiro, “Using Feedback Control of Micro-Flows to Independently Steer Multiple Particles”, Journal of Microelectromechanical Systems (JMEMS), vol 15, no 4, pg 945-956, Aug 2006.
B.Shapiro, E.Smela, “Bending Actuators with Maximum Curvature and Force and Zero Interfacial Stress”, Journal of Intelligent Material Systems and Structures (JIMSS), vol 18, pg 181-186, Feb 2007. (First published online 17 May 2006.) [Invited, for special issue.]
S.Chaudhary*, B.Shapiro, “Arbitrary Steering of Multiple Particles Independantly in an Electroosmotically Driven Microfluidic System”, IEEE Transactions on Control Systems Technology, vol 14, issue 4, pg 669-680, July 2006.
.Armani*, S.Chaudhary*, R.Probst*, S.Walker*, B.Shapiro, “Control of Micro-Fluidic Systems: Two Examples, Results, and Challenges”, International Journal of Robust and Nonlinear Control. vol 15, issue 16, pg 785-

Submitted and Under Review:

R.Probst*, Z.Cummins*, B.Shapiro, “Electrokinetic tweezers: living cells manipulation by vision sensing and feedback control”, Nature Protocols. (Passed editorial review.)
R.Probst*, Z.Cummins*, B.Shapiro, “Steering bacteria: independent control of multiple live swimming cells by vision sensing and electrophoretic feedback actuation”, Lab-On-A-Chip communication (results of immediate interest).

Under Preparation

A.Nacev*, C.Beni, O.Bruno, B.Shapiro, “The Behaviors of Ferro-Magnetic Nano-Particles in Blood Vessels under Applied Magnetic Fields”, Journal of Magnetism and Magnetic Materials. (Paper is 85% complete.)
R.Probst*, J.Lin*, A.Nacev*, Z.Cummins*, A.Komaee*, B. Shapiro “Planar Steering of a Single Ferrofluid Drop by Dynamic Feedback Control of Four Electromagnets at a Distance”, Journal of Magnetism and Magnetic Materials. (Experiments have succeeded. Paper is 40% complete.)
P.Mathai*, A,Liddle, B.Shapiro, “Control of Micro-Object Positions and Orientations by Electroosmotic Feedback Control: Simulations and Control Algorithms”, ACS Nano. (Completed the results – the control algorithms are working. Paper is 30% complete.)
C.Ropp, R.Probst*, Z.Cummins*, R.Kumar, S.Srinivasan, E.Waks, B.Shapiro, “Precision Manipulation of Single Quantum Dots to 200 nm Accuracy by On-Chip Feedback Control”. Nature/Science else Nature Photonics, Optics Express or Applied Physics Letters. (We have achieved flow control of single quantum dots to 200 nm accuracy! Paper is 25% complete.)
B.Shapiro, “On Optimal Algorithms to Focus Chemotherapy to Deep Tumors by Magnetic Control”, IEEE Transactions on Automatic Control. (The research for this paper, the physics, models, simulations, optimization scripts, and control algorithm demonstrations, is 85% done. Paper is 20% done.) [Is part of a major effort to precisely control magnetic drug delivery: to focus drug coated nano-particles to deep tumors.]
B.Shapiro, P.Mathai*, A.Berglund, A.Liddle, “A Review of Position and Orientation Control of Micro and Nano-Scale Objects”. (Paper is 30% complete. This massive review article will take some time to finish, anticipated submission 2010.)
S.Kim*, M.Emmert-Buck, B.Shapiro, “Regions of Breast Cancer Metastases Can Be Poorly Vascularized: Implications for Magnetic Drug Delivery”, Nature Medicine or Pathology. (Analysis, staining, and counting of blood vessels in human autopsy slides is 70% done. Paper is 20% done.)

Refereed Conference Papers: Published, Presented, or Accepted
My students are marked by an asterix (*). Page/article numbers are cited when available.

B.Shapiro, I.Rutel, K.Dormer, “Therapeutic Nano-Particles Magnetic Injector System (MIS)”, Frontiers in the Characterization and Control of Magnetic Carriers, Clemson University, 26-28 April 2009.
M.Armani*, J.Rodriguez-Canales, M.Emmert-Buck, B.Shapiro, E.Smela, “Mapping DNA in Tissues: A Spatially Resolved Array Technique with Integrated Tissue Transfer, DNA Extraction, Amplification and Detection”, Lab-on-a-Chip World Congress, San Francisco, 6-7 Aug 2009.
B.Shapiro, I.Rutel, K.Dormer, “A System to Inject Therapeutically-Coated Magnetic Nano-Particles into the Inner Ear: Design and Initial Validation”, ASME, 3rd International Conference on Micro- and Nanosystems (MNS), Topic: MNS-2 Measurement and Control in Micro and Nanosystems, San Diego, CA, Aug 30 – Sept 2, 2009. [Withdrawn: none of the 3 of us could attend the conference.]
M.E.Piyasena, B.Shapiro, E.Smela, “A New EAP Based on Electroosmotic Flow: Nastic Actuators”, SPIE, EAPAD 2009, San Diego, CA, 8-12 March 2009.
M.Santos*, B.Shapiro, “Relating Satellite Coverage to Orbital Geometry”, AIAA/AAS conference, in Orbital Dynamics, Perturbations, and Stability session, Honolulu, Hawaii, 18-21 Aug 2008.
B.Shapiro, R.Probst*, H.E.Potts, D.A.Diver, A.S.Lubbe, “Dynamic Control of Magnetic Fields to Focus Drug-Coated Nano-Particles to Deep Tissue Tumors”, 7th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Vancouver, BC, 21-24 May 2008.
B.Shapiro, R.Probst*, H.E.Potts, D.A.Diver, A.S.Lubbe, “Control to Concentrate Drug-Coated Magnetic Particles to Deep-Tissue Tumors for Targeted Cancer Chemotherapy”, 46th IEEE Conference on Decision and Control, pg 3901-3906, New Orleans, LA, 12-14 Dec 2007.
P.Mathai*, N.Martins, B.Shapiro, “On the Detection of Gene Network Interconnections using Directed Mutual Information”, Information Theory and Applications workshop, La Jolla, CA, 29 Jan – 2 Feb, 2007.
M.Armani*, S.Chaudhary*, R.Probst*, B.Shapiro, “Steering and Trapping Multiple Particles by Feedback Flow Control: Theory and Experiments”, Applied Physics Society (APS) March meeting, Baltimore, MD, March 2006.
X.Wang, B.Shapiro, E.Smela, “Modeling Charge Transport in Conjugated Polymers”, EAPAD 2006, San Diego, CA, March 2006.
P.Mathai*, B.Shapiro, D.DeVoe, S.Sivanesan, “Modeling and Simulation of Ampholyte Behavior in 2-Dimensional Isoelectric Focusing”, 2005 ASME International Mechanical Engineering Congress on Exposition, Orlando, Florida, 5-11 Nov 2005. (IMECE2005-81854)
M.Armani*, S.Walker*, B.Shapiro, “Modeling and Control of Electrically Actuated Surface Tension Driven Micro-Fluidic Systems”, Joint 2005 International Symposium on Intelligent Control & 13th Mediterranean Conference on Control and Automation (2005 ISIC-MED), pg 131-138, Cyprus, Greece, 27-29 June 2005. [Won best paper in session award.]
S.Fanning*, Y.Liu, M.Christophersen, M.Duerkop, E.Smela, B.Shapiro, “Polypyrrole/Gold Bilayer Characterization”, EAPAD 2005, vol 5759, pg 292-301, San Diego, CA, March 2005, vol
X. Wang, E. Smela, and B. Shapiro, "Modeling Ion Transport in Conjugated Polymers", Second World Congress on Biomimetics, Artificial Muscles, & Nano-Bio, Albuquerque, NM, Dec. 6-8, 2004.
B. Shapiro and E. Smela, "Ion and Electron Transport in PPy Conjugated Polymers (Conducting Plastic) Microactuators", ASME Int'l. Mechanical Engineering Congress, Anaheim, CA. Nov. 13-19, 2004. [B.Shapiro invited speaker.]
X. Wang, B. Shapiro, and E. Smela, "Modeling Conjugated Polymer Actuators: Understanding Ion Transport", ASME Int'l. Mechanical Engineering Congress, Anaheim, CA, Nov. 13-19, 2004.
M.Armani*, S.Chaudhary*, R.Probst*, B.Shapiro, “Using Feedback Control and Micro-Fluidics to Steer Individual Particles”, MEMS 2005, pg 855-858, Miami, Florida. 30 Jan to 3 Feb, 2005. [Accepted as oral presentation. Only 5% of the 750 submitted abstracts were accepted as oral presentations.]
X.Wang, B.Shapiro, E.Smela, “Understanding Ion Transport in Conjugated Polymers”, The International Conference on Synthetic Metals (ICSM) 2004, Wollongong, New South Wales, Australia 28 June to 2 July 2004. [Invited paper.]
X. Wang, E. Smela, and B. Shapiro, "Understanding Ion Transport in Conjugated Polymers", SPIE's 11th Annual Int'l. Symposium on Smart Structures and Materials, EAPAD, San Diego, CA, 15-18 March, 2004, SPIE, Ed. Y. Bar-Cohen, Vol. 5385, 146-154. [Smela invited speaker.]
M.Armani*, S.Chaudhary*, R.Probst*, B.Shapiro, “Micro Flow Control Particle Tweezers”, TAS 2004, Malmo, Sweden, 26-30 September 2004.
B. Shapiro, “Summary of the NSF Workshop on Control and System Integration of Micro- and Nano-Scale Systems”, American Control Conference, Boston, MA, June 30 – July 2, 2004.
X. Tan, A. Modafe, R. Hergert, N. Ghalichechian, B. Shapiro, J.S. Baras, and R. Ghodssi, “Vision-based Microtribological Characterization of Linear Microball Bearings”, ASME/STLE International Joint Tribology Conference: Special Symposia on Contact Mechanics, Long Beach, CA, 24-27 Oct 2004. (TRIB2004-64334)
G.Barrett, E.Smela, B.Shapiro, S.Fanning*, L.H.Oh, M.S.Furst, J.Wallace, P.Sheth, N.Thakor, A.Natarajan, “The Development of a MEMS Based System for the Treatment of Urinary Incontinence”, 19th ASME Nanomechanics conference, Reno, Nevada, 18 May 2004. [Chosen as best presentation at the conference.]
G. Barrett, E. Smela, B. Shapiro, L. H. Oh, J. Wallace, N. Thakor, and A. Natarajan, "Nanotechnology: From Nanobots to Reality and Back Again", G. Barrett invited speaker at Nanotechnology In Biomedical Innovation, Tysons Corner, VA, May 6, 2004, Feynman Beltway Series.
M.Manion*, N.Sergeev, I.,Treise*, B.Shapiro, A.Rasooly, “Hand-held Microfluidics Multi-channel Immunosensor for Detection of Multiple Microbial Toxins Simultaneously”, 2004 Food and Drug Administration (FDA) Science Forum, Washington DC, 18-19 May 2004. [Won the “Clear Science Communication Award” out of 412 competing posters. It is now displayed in the FDA commissioners office.]
B. Shapiro, “Flow Control on the Micro-Scale for Bio-Chemical Sensing and Actuation”, 42nd AIAA Aerospace Sciences Meeting and Exhibit, Reno, Nevada, 5-8 Jan 2004.
S. Walker*, B. Shapiro, “Modeling the Fluid Dynamics of Electro-Wetting on Dielectric (EWOD)”, 2004 Nanotech, Boston, MA, March 7-11, 2004.
B.Shapiro, “Control Challenges in Micro Fluidic Systems and Nanoscale Transport Phenomena”, 2003 IEEE Conference on Decision & Control (CDC 2003), Maui, Hawaii, 9-12 Dec 2003.
S.Chaudhary*, B.Shapiro, “Arbitrary Control of Multiple Particles in a Microfluidic Device”, International Mechanical Engineering Congress and Exposition, Washington DC, 16-21 Nov 2003.
30. B.Shapiro, S.Walker*, N.Fortner* “Modeling Surface Tension under Applied Fields: Energy Methods, Stokes Flow, and Level Sets”, 7TH US National Congress on Computational Mechanics (USNCCM), Alburquerque, New Mexico, 28-31 July 2003. [Invited talk.]
N. Fortner*, B.Shapiro, “Equilibrium and Dynamic Behavior of Micro Flows Under Electrically Induced Surface Tension Actuation Forces”, The 2003 International Conference on MEMS, NANO, and Smart Systems (ICMEMS).
Banff, Alberta, Canada, July 20-23, 2003. [Invited talk.]
B.Shapiro, “Modeling for Design and Control in Micro-Fluidic Systems”, Mathematical Problems in Microscale Systems, 5th International Congress on Industrial and Applied Mathematics (ICIAM), Sydney Australia 7-11 July, 2003. [Invited talk.]
N.Fortner*, B.Shapiro, A.Hightower, “Modeling and Passive Control of Channel Filling for Micro Fluidic Networks with Thousands of Channels”, American Institute of Aeronautics & Astronautics (AIAA) 33rd AIAA Fluid Dynamics Conference and Exhibit, Orlando, FL, 23-26 June 2003. (AIAA-2003-4015)
Y.Liu, L.Oh, S.Fanning*, B.Shapiro, E.Smela, “Fabrication of Folding Microstructures Actuated by Polypyrrole/Gold Bilayer”, Transducers 2003, vol 1, pg 786-789, Boston, June 8-12.
B.Shapiro, H.Moon, R.Garrell, C.J.Kim, “Modeling of Electrowetted SurfaceTension for Addressable Microfluidic Systems: Dominant Physical Effects, Material Dependences, and Limiting Phenomena”, Micro-Electro-Mechanical Systems (MEMS2003), pg 201-205, Kyoto, Japan, 19-23 Jan 2003.
B. Shapiro “Creating Reduced-Order Models for Electronic Systems: An Overview and Suggested Use of Existing Model Reduction and Experimental System Identification Tools”, THERMES 2002, Thermal Challenges in Next Generation Electronic Systems, vol 26, no 1, pg 165-172, Santa Fe, Jan 13-16, 2002. Proceedings published by Millpress, Netherlands.
D. Lin*, D. Wendland, B. Shapiro, R. Ghodssi “Measurement of Rolling Friction for MEMS Applications”. IUVSTA 15th International Vacuum Congress (IVC-15), AVS 48th International Symposium (AVS-48), 11th International Conference on Solid Surfaces (ICSS-11). San Francisco, CA. Oct 28-Nov 2, 2001.
B. Shapiro, N. Fortner*, A. Hightower “Surface Tension Flows in Bent Micro-Channels: An Energy Minimization Theory versus Experiment”, Applied Physics Society, Nano-Scale Physics Applications session. Seattle, March 12, 2000. [Presentation but no published proceedings.]
B.Shapiro, “Model Reduction of Models for MEMS Friction Dynamics”, Dynamics of Micro and Nanoscale Devices and Materials, minisymposium held at the SIAM Pacific Rim Dynamics meeting, August 2000 [Invited talk, no published proceedings.]
B.Shapiro, “Characterizing Mode Localization by Symmetry”, Joint Propulsion Conference, 34th AIAA/ASME/SAE/ASEE, July 1998.
B.Shapiro, B.D.Coller, “Characterizing Optimal Mistuning by Symmetry Arguments”, IEEE Conference on Control Applications, 1997.
B.Shapiro, “Optimal Mistuning: An Analysis of Flutter Boundaries in Turbomachines”, Joint Propulsion Conference, 33rd AIAA/ASME/SAE/ASEE, July 1997.
J. Doyle, J.A. Primbs, B. Shapiro, V. Nevistic. “Nonlinear Games: Examples and Counter-examples”, IEEE Conference on Decision and Control, Dec 1996.

Patents
Two patents have been licensed, marked by [details], 4 more are being considered for licensing.
My students are marked by an asterix (*).

B.Shapiro, I.B.Rutel, “A Magnetic System to Push Magnetic Carriers”. Patent disclosure sent to OTC 27 Oct 2008. Provisional filed 25 Feb 2009. (Include all other ideas, treatment of heart, eye, skin, gut, etc. in the patent when we write it. The examiner will break into multiple patents anyway. For filing of the patent in a year, ask Felicia to have June Cohan do this one, the same person and firm that did my ‘deep tumors magnetic drug targeting’ patent.) [Patent is being considered for field of use licensing by either Charlesson LLC (for treatment of eye diseases) or by Cumbre Inc (for treatment of drug resistant bacteria).]
B.Shapiro, M.Emmert-Buck, “Methods and Systems Using Therapeutic, Diagnostic or Prophylactic Magnetic Agents”. Patent disclosure sent to OTC at UMD on 5 May 2008. Provisional patent filed 19 May 2008. Full patent filed 19 May 2009. [I offered to pay the extra filing costs to go from 20 claims to 71, a cost of $2,500, from my grants.]
R.Probst, B.Shapiro, “Micro Fluidic Device that Allows 3 Dimensional Control of Nano and Micro Particles by Electroosmotic Flow (EOF) Actuation”. Patent disclosure received by OTC at UMD on 12 March 2008.
B.Shapiro, E.Waks, “Positioning Quantum Dots in Devices by Electroosmotic Feedback Control”. Patent disclosure not yet filed (George Letscher is the contact at OTC). Patent disclosure submitted to OTC at UMD on 20 Dec 2007.
E.Smela, P.Abshire, B.Shapiro “Microfluidic System for Sample Preparation”. Provisional patent filed by OTC on 14 Oct 2008. Patent disclosure submitted to OTC at UMD on 10 Dec 2007. (Full patent due 13 Oct 2009.) [Patent will be considered for licensing by Innovative Biosensors Inc.]
B.Shapiro, H.Potts, D.Diver, R.Probst*, “Methods and Systems for Magnetic Focusing of Therapeutic, Diagnostic or Prophylactic Agents to Deep Tumors”. Patent filed 11 Dec 2008. Provisional patent filed 11 Dec 2007. Patent disclosure submitted to OTC at UMD on 12 March 2007. (Have done extensive patent search, June Cohan at Edell, Shapiro, and Finnan also did a patent search [Dec 07], no one has done/patented this.) [Patent is being considered for licensing by PulseTherpeutics, a company for magnetic drug delivery for treatment of brain tumors.]
B.Shapiro, S.Quake, “Feedback Control of Protein Crystal Growth”. Patent disclosure submitted to OTC at UMD on 30 June 2006.
B.Shapiro, S.Quake, “Nanoparticle Nucleation of Protein Crystal Growth”. Patent disclosure submitted to OTC at UMD on 30 June 2006.
M.Emmert-Buck, M.Armani, B.Shapiro, E.Smela, J.Gillespie, M.Tangrea, J. Rodriguez-Canales, R.Chuaqui, “Micro-Array for Nucleotide Amplification with 2D Positional Information”. Provisional patent filed 30 Jan 2009. (Provisional patent submitted to UMD OTC office Nov 2005, but handled by NIH.) (Full patent due 29 Jan 2010.) [Patent is licensed (through NIH) by BioNanoServe Inc. which is commercializing the technology.]
B.Shapiro, E.Smela “Electrically driven microfluidic pumping for actuation”. Full patent granted 3 March 2009. Filed at patent office 9 Sep 2005. Provisional patent filed by OTC office Sept 2004.
B.Shapiro, E.Smela, P.Abshire, D.Wirtz “Cell Sensor Based Pathogen Detection”. Provisional patent filed by OTC office Sept 2004. Submitted to patent office 30 Aug 2005. [Awarded: Invention of the year in 2004 at the University of Maryland within the Physical Science category. One winner was chosen in each of the six categories by the Office of Technology Commercialization and by an external review process.] (Application not yet published on USPTO website (searched 6/13/07). In Nov 2007, USPTO required restriction of claims, we responded with choosing group 1 claims for continued prosecution, other claims will be resubmitted as separate applications but keeping the original filing date.)
B.Shapiro, S.Chaudhary*, M.Armani*, R.Probst* “Arbitrary and Simultaneous Control of Multiple Particles in Micro-Fluidic Systems”. Invention of disclosure submitted to UMD Office of Commercialization on 14 Dec 2002. Patent filed 5 Sept 2004. [One of three finalists for invention of the year 2003 at the University of Maryland.] Claims in negotiation with USPTO. (Need to file withdrawn claims and device claims while this patent is still pending, meaning, before OTC pays the final filing fee. If OTC does not want to pick up this patent I myself will write and file the device claims patent.) [Patent will be considered for licensing by Innovative Biosensors Inc.]
B. Shapiro, “Rotors with Mistuned Blades”. Patent issued Nov 30, 1999. [Patent is licensed by Pratt & Whitney, a subsidiary of United Technologies Corporation, as of May 2006.]

Software

B. Shapiro, “Mistuning Analysis by Symmetry Techniques (MAST)”, 1999.

Fellowships, Prizes, and Awards.

2009 Fulbright Scholar (to Germany) for precision control of magnetic drug delivery to focus chemotherapy to deep tissue tumors. Host: Andreas Lubbe, Director Cecilienklinik (a 750 bed hospital), Bad Lippspringe, Germany.
2008 Japan-America Frontiers of Engineering Symposium, organized by the National Academy of Engineers and the Japan Science and Technology Agency, “that brings together 100 outstanding engineers (ages 30-45) from U.S. companies, universities, and government labs to discuss leading-edge research and technical work across a range of engineering fields”.
2007-2008 Outstanding Professor AIAA award. Each year students in the Aerospace department vote for the “… professor deemed to be the best teacher in courses over the past academic year”.
2007, nominated by Maryland Science Academy for Outstanding Young Engineer award.
2007, plenary talk for NanoDay at University of Maryland: “On control of micro-scale systems: combining modeling, control, sensing, and actuation to achieve new capabilities”.
2007, briefed JASONs Summer study on “Control in Micro-Fluidic Systems”. The JASONs are a group of 40-50 tenured faculty with high credentials, including Nobel laureates, who advise government agencies on emerging technology research areas.
2006, selected for membership in Council of Outstanding Young Engineering Alumni, Georgia Institute of Technology. Membership is reserved for alumni of the engineering college under forty years of age who have distinguished themselves through professional practice and or service to GT, the profession, or society-at-large.
2005-2006 Outstanding Professor AIAA award.
Invited by the National Science Foundation to be a part of the US delegation for US-Japan Young Researcher in Nano Program, in US March 2006, in Japan Oct 2006.
Won best paper in session award for conference paper: M.Armani, S.Walker, B.Shapiro, “Modeling and Control of Electrically Actuated Surface Tension Driven Micro-Fluidic Systems”, Joint 2005 International Symposium on Intelligent Control & 13th Mediterranean Conference on Control and Automation (2005 ISIC-MED), Cyprus, Greece, 27-29 June 2005.
Patent awarded Invention of the year in 2004 at the University of Maryland within the Physical Science category. One winner was chosen in each of the six categories by the Office of Technology Commercialization and by an external review process. B.Shapiro, E.Smela, P.Abshire, D.Wirtz “Cell Sensor Based Pathogen Detection”. Provisional patent filed by OTC office Sept 2004.
Awarded ‘rainmaker’ status by the Vice President of Research, University of Maryland for securing major contract and grant support. Sept 2004.
Conference paper chosen as best presentation at conference: G.Barrett, E.Smela, B.Shapiro, S.Fanning, L.H.Oh, M.S.Furst, J.Wallace, P.Sheth, N.Thakor, A.Natarajan, “The Development of a MEMS Based System for the Treatment of Urinary Incontinence”, 19th ASME Nanomechanics conference, Reno, Nevada, 18 May 2004.
Invention of the year finalist, one of three for invention of the year 2003 at the University of Maryland. B.Shapiro, S.Chaudhary, M.Armani, R.Probst “Arbitrary and Simultaneous Control of Multiple Particles in Micro-Fluidic Systems”. Invention of disclosure submitted to UMD Office of Commercialization on 14 Dec 2002. Patent filed 5 Sept 2004.
2003 NSF CAREER Award “CAREER: Feedback Control of Micro-Fluidic Packets and the Bio-Particles Within Them”, funded by Dr. Maria Burka (CTS) and Dr. Kishan Baheti (ECS) for research on modeling and control of bio-chemical micro flows.
1995-98 NSF fellowship for PhD studies.

For more detailed information, download Full CV in doc format

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